In 2003 Thrice signed up with Island Records and released The Artist In The Ambulance, which featured more structured songs while keeping true to their hardcore influences. In 2005 a DVD outlining their entire career to date was released under the title If We Could Only See Us Now. It included a CD with live tracks from the Apple Store and various b-sides.

Thrice released their fourth full-length album, Vheissu, on October 18, 2005. The album was characterized by many critics as being experimentally different, using non-traditional Thrice elements in the process. From keyboard melodies ("For Miles") to Japanese music-box undertones ("Music Box") to chain gang chant choruses ("The Earth Will Shake"), Vheissu introduced a new sound to the band's post-hardcore roots. UK producer Steve Osborne, whose past credits include many Brit-pop hits, was sought by Thrice to gain a new perspective on the songwriting process, enabling the band to expand their musical influences and produce a different album. The album garnered widespread critical acclaim and peaked at #15 on the Billboard 200.

The band releasedRed Sky, an EP comprised of various b-sides as well as live recordings, shortly after Vheissu.

Thrice released the first and second volume of The Alchemy Index, a highly experimental project based on the four traditional elements (fire, water, earth, and air), on October 16th 2007. Over the summer Thrice parted ways with Island records and signed with Vagrant. The Alchemy Index Vols. I & II - Fire & Water was released on October 16, 2007, and sold 28,000 copies in its first week. The album consists of the first two volumes, Fire and Water, and features 12 songs, 6 on each disk. The third and fourth volumes, Air & Earth were released on April 15, 2008.

The "Fire" disc features the heavier post-hardcore sound traditional Thrice fans will quickly embrace, harking back to their pre-Vheissu albums. The "Water" disc, however, is comprised of ambient songs similar to those found in Vheissu, Thrice's previous album release. The "Air" disc brings a whole new element of electronic elements and delayed guitar riffs to Thrice's sound. In "Earth", much like Dustin Kensrue's solo album, "Please Come Home", Thrice introduces an indie-folk sound combining intricate piano and acoustic guitar.

Thrice's sixth studio album Beggars was released digitally through Vagrant Records in the UK on August 9, 2009 and in the US on August 11 with a physical release containing bonus material pencilled in for September 15. These dates deviate from the original proposed release date of October 13 because of a leak via Vagrant Records web player, which has meant the artwork for the album has also changed. The first single to be taken from the album is All The World Is Mad and was first made available through Guitar Hero: World Tour on July 23.

Dustin Kensrue has described the album as being "more visceral and more raw - both in the songwriting and in the overall sound. It moves with a different energy than any of our past records. It was born out of us playing together in a room, almost as a backlash to the giant headgame that was The Alchemy Index" and has been well received critically.

Thrice is an American rock band from Irvine, California, formed in 1998. The group was founded by guitarist/vocalist Dustin Kensrue and guitarist Teppei Teranishi while they were in high school.

Early in their career, the band was known for fast, hard music based in heavily distorted guitars, prominent lead guitar lines, and frequent changes in complex time signatures." This style is exemplified on their second album, The Illusion of Safety (2002) and their third album The Artist in the Ambulance (2003). Their fourth album Vheissu (2005) made significant changes by incorporating electronic beats, keyboards, and more mature and nuanced songwriting. Their fifth effort was a quadruple album entitled The Alchemy Index (2007/2008), released as two sets of two CDs that together make a 4-part, 24-song cycle. Each of the four 6-song EPs of the Alchemy Index features significantly different styles, based on different aspects of the band's musical aesthetic which reflect the elemental themes of fire, water, air and earth, both lyrically and musically. The band's sixth album, entitled Beggars, was released on August 11, 2009.

Each album released by Thrice has had a portion of its sales proceeds donated to a new charitable organization.